Rapid Reversal of Anticoagulation Reduces Hemorrhage Volume in a Mouse Model of Warfarin-Associated Intracerebral Hemorrhage
نویسندگان
چکیده
منابع مشابه
Experimental model of warfarin-associated intracerebral hemorrhage.
BACKGROUND AND PURPOSE Future demographic changes predict an increase in the number of patients with atrial fibrillation. As long-term anticoagulation for the prevention of ischemic strokes becomes more prevalent, the burden of warfarin-associated intracerebral hemorrhage (W-ICH) is likely to grow. However, little is known about the clinical aspects and pathophysiologic mechanisms of W-ICH. Thi...
متن کاملEmergency reversal of anticoagulation after intracerebral hemorrhage.
BACKGROUND AND PURPOSE Although intracerebral hemorrhage is one of the most serious complications during oral anticoagulant therapy, there are no guidelines on emergency treatment with respect to reversal of anticoagulation effect in these patients. METHODS We retrospectively compared laboratory data and clinical features in 17 cases of anticoagulant-related intracerebral hemorrhage treated w...
متن کاملResumption of oral anticoagulation after warfarin-associated intracerebral hemorrhage: yes.
A hematology/thrombosis consultation for a patient admitted with warfarin-associated intracerebral hemorrhage (ICH) should take into account the indication for anticoagulation, the treatment history with warfarin, any possible precipitating risk factors for the hemorrhage, the location of the hematoma, and the condition of the patient. Finally, the balance between the risk for ischemic stroke w...
متن کاملPoor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal.
BACKGROUND AND PURPOSE Anticoagulant-associated intracranial hemorrhage (aaICH) presents with larger hematoma volumes, higher risk of hematoma expansion, and worse outcome than spontaneous intracranial hemorrhage. Prothrombin complex concentrates (PCCs) are indicated for urgent reversal of anticoagulation after aaICH. Given the lack of randomized controlled trial evidence of efficacy, and the p...
متن کاملAcute Management of Anticoagulation-Associated Intracerebral Hemorrhage
One of the most serious forms of stroke is intracerebral hemorrhage (ICH) as fewer than 30 % of patients recover to functional independence and the one-year mortality rate of over 50 % is very high [1–3]. In hemorrhagic stroke, oral anticoagulation-associated intracerebral hemorrhage (OAC-ICH) is of particular concern because it is associated with larger hemorrhage volumes, increased ventricula...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2009
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2009.27